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Article

A framework for mutational signature analysis based on DNA shape parameters.

PloS one - 1 Jan 2022

Karolak Aleksandra, Levatić Jurica, Supek Fran

Abstract excerpt

The mutation risk of a DNA locus depends on its oligonucleotide context. In turn, mutability of oligonucleotides varies across individuals, due to exposure to mutagenic agents or due to variable efficiency and/or accuracy of DNA repair. Such variability is captured by mutational signatures, a mathematical construct obtained by a deconvolution of mutation frequency spectra across individuals. There is a need to...

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Identifiers

PMID: 35015788
DOI: 10.1371/journal.pone.0262495
PMCID: PMC8752002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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