Article

MutSignatures: An R Package for Extraction and Analysis of Cancer Mutational Signatures

2020-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Cancer cells accumulate somatic mutations as result of DNA damage and inaccurate repair mechanisms. Different genetic instability processes result in distinct non-random patterns of DNA mutations, also known as mutational signatures. We developed mutSignatures , an integrated R-based computational framework aimed at deciphering DNA mutational signatures. Our software provides advanced functions...

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Literature Corpus work: 8cd8aa16-aa4d-5571-8f60-773f815e92cb
DOI: 10.1101/2020.03.15.992826

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