N-Orbit: towards a universal model and metric for comparing tissue microenvironments

Abstract excerpt

<h4>SUMMARY</h4> Advances in spatial omics technologies have greatly expanded our ability to explore tissue microenvironments (TMEs) across development and disease. Yet a theoretical framework for modeling and comparing tissue architecture in diverse biological contexts remains lacking. We introduce, N-Orbit , a mathematical model that captures both cell type composition and spatial relationships within tissue c...

Topics

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• Algorithms
• Cluster Analysis
• Neural Networks, Computer
• Phenotype

Identifiers and source

Literature Corpus work

1458b814-2460-5f1c-8071-0aeca48c64e7

DOI

10.1101/2025.04.23.650192