MONTAGE: A Computation Framework to Identify Spatially Resolved Functional Enrichment Gradients in the Tissue Microenvironment via Spatial Communities

Abstract excerpt

Single-cell spatial-omics has advanced our understanding of how tumor microenvironment contributes to cancer progression. However, most single-cell spatial-omics studies focus on cell types and neighborhoods, offering limited information about functional and clinical relevance of cellular organization. We introduce MONTAGE, a computational framework to reconstruct, functionally analyze, and identify clinically rel...

Topics

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• Algorithms
• Cancer Cells and Metastasis
• Cancer Genomics and Diagnostics
• Cluster Analysis
• Neural Networks, Computer
• Phenotype
• Radiomics and Machine Learning in Medical Imaging
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

8b76d8bc-c2f7-5438-92ed-cdbc450e51d3

DOI

10.1101/2025.04.30.651486