SpNeigh: spatial neighborhood and differential expression analysis for high-resolution spatial transcriptomics

Abstract excerpt

Spatial transcriptomics technologies such as Xenium, MERFISH, and Visium HD enable high-resolution profiling of gene expression while preserving tissue architecture. However, most computational methods for spatial analysis do not explicitly model local tissue context, such as boundaries, neighborhoods, or gradients. Here we present SpNeigh, an R package for spatial neighborhood analysis and spatially-aware differe...

Topics

Open a Topic to create a Post that cites this publication.

• Arthritis, Rheumatoid
• Gene Expression Profiling
• Kidney
• Phenotype
• Technology
• Transcriptome

Identifiers and source

Literature Corpus work

ea2e91cd-8759-5788-8db0-d68ba1a188e9

DOI

10.1101/2025.11.07.687304