geneSCOPE: gene Spatial Co-Occurrence of Pairwise Expression

Abstract excerpt

Spatial transcriptomics captures neighborhood–dependent gene expression, but existing workflows do not always fully account for measurement scale and often treat space implicitly. We present geneSCOPE, a framework that integrates ecology–inspired statistics with network analysis. Molecules are binned on a grid whose width is chosen near the mode of the per–gene unit–invariant knee (UIK) distribution derived from M...

Topics

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• Algorithms
• Cancer Cells and Metastasis
• Cell Image Analysis Techniques
• Cluster Analysis
• Neural Networks, Computer
• Phenotype
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

057e774a-0860-5afc-ad75-3b807e7854b2

DOI

10.64898/2025.12.03.691993