Cophenetic Spatial Topology Embedding reveals multiscale tissue architecture in spatial omics

Abstract excerpt

The spatial organization of tissues emerges from cell interactions across multiple scales, yet current spatial omics analysis tools often emphasize local neighborhoods and may not summarize broader tissue architecture. Here we introduce Cophenetic Spatial Topology Embedding (COSTE), a computational framework that embeds directed nearest-neighbor distance profiles into a hierarchical metric space without requiring...

Topics

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• Algorithms
• Cluster Analysis
• Neural Networks, Computer
• Phenotype

Identifiers and source

Literature Corpus work

e9d24343-45cb-5266-a43a-0f5e9d9d470e

DOI

10.64898/2026.05.26.727847