Article

Conserved principles of spatial biology define tumor heterogeneity and response to immunotherapy

2024-10-22

Abstract excerpt

<h4>Summary</h4> The complexity of tumor microenvironments (TMEs) poses a substantial challenge to understanding tumor heterogeneity and clinical outcomes. By studying an ensemble of 262 diverse solid tumors, we uncovered a conserved, hierarchical architecture of transcriptionally covarying regions we term Spatial Groups (SGs). SGs corresponded to discrete biological units as benchmarked against multiple spatial...

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Literature Corpus work: 64a26675-7e91-5d92-b69c-b41fb082796d
DOI: 10.1101/2024.10.18.619136

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