Article

Star-Motifs: Revealing Single-Cell Spatiotypes from Routine Histology Using Star-Convex Neighborhoods

2025-11-10

Abstract excerpt

The tumor microenvironment (TME) is a dynamic interplay among cancer, immune, and stromal cells that profoundly influences tumor growth, progression, and treatment response. Although recent spatial transcriptomics and multiplex imaging technologies offer fine-grained insights into the TME, their high cost and lengthy turnaround times limit routine clinical use. In contrast, whole slide images (WSIs) of Hematoxylin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f928262-106e-5bb7-b124-b949c00ec2d3
DOI: 10.1101/2025.11.07.687248

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Star-Motifs: Revealing Single-Cell Spatiotypes from Routine Histology Using Star-Convex NeighborhoodsDOI 10.1101/2025.11.07.687248Read

Towards interpretable molecular and spatial analysis of the tumor microenvironment from digital histopathology images with HistoTME-v2Semantic proximity Read

SPACE-GM: geometric deep learning of disease-associated microenvironments from multiplex spatial protein profilesSemantic proximity Read

Cellohood: multi-granular discovery of cellular neighborhoods with a permutation-invariant set transformer auto-encoderSemantic proximity Read

hoodscanR: profiling single-cell neighborhoods in spatial transcriptomics dataSemantic proximity Read

Spatial Topology Reveals Biologically Distinct Recurrent Motifs in Colorectal CancerSemantic proximity Read

Conserved principles of spatial biology define tumor heterogeneity and response to immunotherapySemantic proximity Read

Pan-Cancer Spatial Profiling Reveals Conserved Subtypes and Niches of Cancer-Associated FibroblastsSemantic proximity Read

Hist2Cell: Deciphering Fine-grained Cellular Architectures from Histology ImagesSemantic proximity Read

Learning predictive models of tissue cellular neighborhoods from cell phenotypes with graph poolingSemantic proximity Read

Tissue as Landscape: An Interpretable Ecological Framework for Quantifying Whole-Slide Spatial Architecture and Cancer PrognosisSemantic proximity Read

STHD: probabilistic cell typing of single Spots in whole Transcriptome spatial data with High DefinitionSemantic proximity Read

QUICHE reveals structural definitions of anti-tumor responses in triple negative breast cancerSemantic proximity Read