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NicheScope: Identifying Multicellular Niches and Niche-Regulated Cell States in Spatial Transcriptomics

2025-08-25

Abstract excerpt

The functional state of a cell is intrinsically linked to its local microenvironment, or cell niche, a complex milieu formed by multiple interacting cell types. Deciphering how these multicellular niches regulate cell states is fundamental to understanding tissue biology and disease mechanisms, yet remains challenging with current computational approaches. Here, we present NicheScope, a computational framework for...

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Literature Corpus work
4e5f90f0-a5e3-5860-8a23-9cf7abbac97d
DOI
10.1101/2025.08.21.671426
Open publication

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NicheScope: Identifying Multicellular Niches and Niche-Regulated Cell States in Spatial TranscriptomicsDOI 10.1101/2025.08.21.671426
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