Article

Single-cell somatic copy number variants in brain using different amplification methods and reference genomes

2023-08-08

Abstract excerpt

The presence of somatic mutations, including copy number variants (CNVs), in the brain is well recognized. Comprehensive study requires single-cell whole genome amplification, with several methods available, prior to sequencing. We compared PicoPLEX with two recent adaptations of multiple displacement amplification (MDA): primary template-directed amplification (PTA) and droplet MDA, across 93 human brain cortical...

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Literature Corpus work: 14323780-0b1f-5995-931a-009628e54a03
DOI: 10.1101/2023.08.07.552289

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