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Single-cell somatic copy number variants in brain using different amplification methods and reference genomes

9 Oct 2024

Abstract excerpt

The presence of somatic mutations, including copy number variants (CNVs), in the brain is well recognized. Comprehensive study requires single-cell whole genome amplification, with several methods available, prior to sequencing. Here we compare PicoPLEX with two recent adaptations of multiple displacement amplification (MDA): primary template-directed amplification (PTA) and droplet MDA, across 93 human brain...

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PMID: 39384904
DOI: 10.1038/s42003-024-06940-w

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