Article

Transcriptomic signatures of nine high-risk neuropsychiatric copy number variants in human brain cells

2024-09-22

Abstract excerpt

Large, recurrent copy number variants (CNVs) are among the strongest risk factors for neuropsychiatric conditions, contributing to multiple phenotypes with overlapping psychiatric and cognitive symptoms. However, the molecular basis of this convergent risk remains unknown. We evaluated the human brain transcriptome in carriers of nine high-risk neuropsychiatric CNVs and matched non-carriers using single nucleus RN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ce9b934-c77b-5369-ba9d-1e4269198a0a
DOI: 10.1101/2024.09.19.613680

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic signatures of nine high-risk neuropsychiatric copy number variants in human brain cellsDOI 10.1101/2024.09.19.613680Read

Structural and functional brain alterations revealed by neuroimaging in CNV carriers.Semantic proximity Read

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergenceSemantic proximity Read

Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders.Semantic proximity Read

Copy Number Variations in Neuropsychiatric Disorders.Semantic proximity Read

Copy number variation and neuropsychiatric illness.Semantic proximity Read

Somatic copy number variants in neuropsychiatric disorders.Semantic proximity Read

Neuropsychiatric copy number variants exert shared effects on human brain structureSemantic proximity Read

Genomic structural variation in psychiatric disorders.Semantic proximity Read

Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies.Semantic proximity Read

Population-based Risk of Psychiatric Disorders Associated with Recurrent CNVsSemantic proximity Read

A Survey of Copy Number Variants Associated with Neurodevelopmental Disorders in a Large-Scale, Multi-Ancestry BiobankSemantic proximity Read

Association of copy number variation across the genome with neuropsychiatric traits in the general population.Semantic proximity Read