Article

PARG establishes a functional module with BRCA1-BARD1 that controls DNA repair pathway choice during gametogenesis

2022-06-17

Abstract excerpt

<h4>ABSTRACT</h4> During meiosis, accurate chromosome segregation relies on the formation of programmed DNA double-strand breaks (DSBs). These are in turn repaired by homologous recombination (HR), generating physical attachments between the parental chromosomes called crossovers (COs). Fewer breaks yield recombinant outcomes, while CO-independent mechanisms are employed for repairing the majority of lesions. The...

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Literature Corpus work: 0c30b755-a560-5260-8a76-6ba267721ca1
DOI: 10.1101/2022.06.14.496162

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