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Article

Heterochromatin protein 1 is recruited to various types of DNA damage.

The Journal of cell biology - 18 May 2009

Luijsterburg Martijn S, Dinant Christoffel, Lans Hannes, Stap Jan, Wiernasz Elzbieta, Lagerwerf Saskia, Warmerdam Daniël O, Lindh Michael, Brink Maartje C, Dobrucki Jurek W, Aten Jacob A, Fousteri Maria I, Jansen Gert, Dantuma Nico P, Vermeulen Wim, Mullenders Leon H F, Houtsmuller Adriaan B, Verschure Pernette J, van Driel Roel

Abstract excerpt

Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-alpha, HP1-beta, and HP1-gamma are recruited to ultraviolet (UV)-induced DNA damage and double-strand breaks (DSBs) in human cells. This response to DNA damage requires the chromo shadow domain of HP1 and is independent of H3K9...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19451271
DOI: 10.1083/jcb.200810035
PMCID: PMC2711568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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