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Article

BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.

Nature communications - 17 Jul 2020

Kamp J A, van Schendel R, Dilweg I W, Tijsterman M

Abstract excerpt

Failure to preserve the integrity of the genome is a hallmark of cancer. Recent studies have revealed that loss of the capacity to repair DNA breaks via homologous recombination (HR) results in a mutational profile termed BRCAness. The enzymatic activity that repairs HR substrates in BRCA-deficient conditions to produce this profile is currently unknown. We here show that the mutational landscape of BRCA1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32680986
DOI: 10.1038/s41467-020-17455-3
PMCID: PMC7368036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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