Article
Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring.
Cell cycle (Georgetown, Tex.) - 1 May 2008
Tamminga Jan, Koturbash Igor, Baker Mike, Kutanzi Kristy, Kathiria Palak, Pogribny Igor P, Sutherland Robert J, Kovalchuk Olga
Abstract excerpt
It is now well accepted that parental whole body irradiation causes transgenerational genome and epigenome instability in the offspring. The majority of human exposures to radiation, such as therapeutic and diagnostic irradiation, are localized and focused. The potential of localized body-part exposures to affect the germline and thus induce deleterious changes in the progeny has not been studied. To investigate...
Topics
- Abnormalities, Radiation-Induced
- Animals
- Bone Marrow
- Bystander Effect
- Cell Proliferation
- Cranial Irradiation
- DNA Damage
- Epigenesis, Genetic
- Genomic Instability
- Germ Cells
- Male
- Mutation
- Rats