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Article

ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline.

PLoS genetics - 1 Oct 2014

Kim Hyun-Min, Colaiácovo Monica P

Abstract excerpt

Germline mutations in DNA repair genes are linked to tumor progression. Furthermore, failure in either activating a DNA damage checkpoint or repairing programmed meiotic double-strand breaks (DSBs) can impair chromosome segregation. Therefore, understanding the molecular basis for DNA damage response (DDR) and DSB repair (DSBR) within the germline is highly important. Here we define ZTF-8, a previously...

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Identifiers

PMID: 25329393
DOI: 10.1371/journal.pgen.1004723
PMCID: PMC4199516

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