Article

<i>But Mouse, you are not alone</i> : On some severe acute respiratory syndrome coronavirus 2 variants infecting mice

2021-08-05

Abstract excerpt

In silico predictions combined with in vitro, in vivo and in situ observations collectively suggest that mouse adaptation of the SARS-CoV-2 virus requires an aromatic substitution in position 501 or position 498 (but not both) of the spike protein’s receptor binding domain. This effect could be enhanced by mutations in positions 417, 484, and 493 (especially K417N, E484K, Q493K and Q493R), and to a lesser extent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 13fce7b5-24ee-587a-8455-e5241002ac00
DOI: 10.1101/2021.08.04.455042

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>But Mouse, you are not alone</i> : On some severe acute respiratory syndrome coronavirus 2 variants infecting miceDOI 10.1101/2021.08.04.455042Read

"But Mouse, You Are Not Alone": On Some Severe Acute Respiratory Syndrome Coronavirus 2 Variants Infecting Mice.Semantic proximity Read

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.Semantic proximity Read

Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y.Semantic proximity Read

Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in miceSemantic proximity Read

Toll-Like Receptor Agonist R848 Protects Mice from Lethal SARS-CoV-2 InfectionsSemantic proximity Read

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2Semantic proximity Read

Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J miceSemantic proximity Read

The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human seraSemantic proximity Read

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.Semantic proximity Read

Emerging SARS-CoV-2 variants expand species tropism to murinesSemantic proximity Read

Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission routeSemantic proximity Read

Comparative characterization of SARS‐CoV‐2 variants of concern and mouse‐adapted strains in miceSemantic proximity Read