Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice

1 May 2021

Abstract excerpt

BACKGROUND: An ideal animal model to study SARS-coronavirus 2 (SARS-CoV-2) pathogenesis and evaluate therapies and vaccines should reproduce SARS-CoV-2 infection and recapitulate lung disease like those seen in humans. The angiotensin-converting enzyme 2 (ACE2) is a functional receptor for SARS-CoV-2, but mice are resistant to the infection because their ACE2 is incompatible with the receptor-binding domain (RBD)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Long-Term Effects of COVID-19
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33993052
DOI: 10.1016/j.ebiom.2021.103381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in micePMID 33993052Read ↗

Toll-Like Receptor Agonist R848 Protects Mice from Lethal SARS-CoV-2 InfectionsSemantic proximity Read ↗

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2Semantic proximity Read ↗

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.Semantic proximity Read ↗

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2Semantic proximity Read ↗

Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J miceSemantic proximity Read ↗

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasuresSemantic proximity Read ↗

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.Semantic proximity Read ↗

Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19Semantic proximity Read ↗

The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human seraSemantic proximity Read ↗

<i>But Mouse, you are not alone</i> : On some severe acute respiratory syndrome coronavirus 2 variants infecting miceSemantic proximity Read ↗

Determinants of susceptibility to SARS-CoV-2 infection in murine ACE2.Semantic proximity Read ↗

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.