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Article

"But Mouse, You Are Not Alone": On Some Severe Acute Respiratory Syndrome Coronavirus 2 Variants Infecting Mice.

ILAR journal - 31 Dec 2021

Kuiper Michael J, Wilson Laurence O W, Mangalaganesh Shruthi, Lee Carol, Reti Daniel, Vasan Seshadri S

Abstract excerpt

In silico predictions combined with in vitro, in vivo, and in situ observations collectively suggest that mouse adaptation of the severe acute respiratory syndrome 2 virus requires an aromatic substitution in position 501 or position 498 (but not both) of the spike protein's receptor binding domain. This effect could be enhanced by mutations in positions 417, 484, and 493 (especially K417N, E484K, Q493K, and...

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Identifiers

PMID: 35022734
DOI: 10.1093/ilar/ilab031
PMCID: PMC9236659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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