Article
Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.
PLoS pathogens - 1 Apr 2023
Ni Dongchun, Turelli Priscilla, Beckert Bertrand, Nazarov Sergey, Uchikawa Emiko, Myasnikov Alexander, Pojer Florence, Trono Didier, Stahlberg Henning, Lau Kelvin
Abstract excerpt
Investigation of potential hosts of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is crucial to understanding future risks of spillover and spillback. SARS-CoV-2 has been reported to be transmitted from humans to various animals after requiring relatively few mutations. There is significant interest in describing how the virus interacts with mice as they are well adapted to human environments,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.