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Emerging SARS-CoV-2 variants expand species tropism to murines

22 Oct 2021

Abstract excerpt

BACKGROUND: Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-CoV-2 variants, including B.1.1.7, B.1.351, P.1, and P.3, contain mutations in spike that has been suggested to associate with an increased recognition of mouse ACE2, raising the postulation that these SARS-CoV-2 variants may have evolved to expand species tropism to wildtype mouse and potentially other murines. Our study...

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PMID: 34689086
DOI: 10.1016/j.ebiom.2021.103643

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