Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.

doi:10.1038/s41467-022-30763-0

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Article

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.

Nature communications - 7 Jul 2022

Rathnasinghe Raveen, Jangra Sonia, Ye Chengjin, Cupic Anastasija, Singh Gagandeep, Martínez-Romero Carles, Mulder Lubbertus C F, Kehrer Thomas, Yildiz Soner, Choi Angela, Yeung Stephen T, Mena Ignacio, Gillespie Virginia, De Vrieze Jana, Aslam Sadaf, Stadlbauer Daniel, Meekins David A, McDowell Chester D, Balaraman Velmurugan, Corley Michael J, Richt Juergen A, De Geest Bruno G, Miorin Lisa, Krammer Florian, Martinez-Sobrido Luis, Simon Viviana, García-Sastre Adolfo, Schotsaert Michael

Abstract excerpt

Due to differences in human and murine angiotensin converting enzyme 2 (ACE-2) receptor, initially available SARS-CoV-2 isolates could not infect mice. Here we show that serial passaging of USA-WA1/2020 strain in mouse lungs results in "mouse-adapted" SARS-CoV-2 (MA-SARS-CoV-2) with mutations in S, M, and N genes, and a twelve-nucleotide insertion in the S gene. MA-SARS-CoV-2 infection causes mild disease, with...

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PMID: 35798721
DOI: 10.1038/s41467-022-30763-0
PMCID: PMC9261898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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