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Article

Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y.

Biology direct - 5 Jun 2022

Zhu Yichao, Zhou Wenzhao, Niu Zubiao, Sun Jiayi, Zhang Zhengrong, Li Qinqin, Zheng You, Wang Chenxi, Gao Lihua, Sun Qiang

Abstract excerpt

BACKGROUND: Rodents, such as mice, are vulnerable targets, and potential intermediate hosts, of SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, and Omicron. N501Y in the receptor-binding domain (RBD) of Spike protein is the key mutation dictating the mouse infectivity, on which the neighboring mutations within RBD have profound impacts. However, the impacts of mutations outside RBD on N501Y-mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35658928
DOI: 10.1186/s13062-022-00325-x
PMCID: PMC9167559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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