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Article

Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature.

Frontiers in immunology - 1 Jan 2021

Sugrue Jamie A, Bourke Nollaig M, O'Farrelly Cliona

Abstract excerpt

Type I interferons (IFN-I) and their cognate receptor, the IFNAR1/2 heterodimer, are critical components of the innate immune system in humans. They have been widely explored in the context of viral infection and autoimmune disease where they play key roles in protection against infection or shaping disease pathogenesis. A false dichotomy has emerged in the study of IFN-I where interferons are thought of as...

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Identifiers

PMID: 34917078
DOI: 10.3389/fimmu.2021.757249
PMCID: PMC8669998

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