Article

Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules

2025-01-22

Abstract excerpt

<h4>Summary</h4> Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), there is a relative paucity of studies at the protein level. Here, we perform a deep, multi-omic characterization (epigenome, transcriptome and proteome) of HSCs carrying a loss-of-function mutation in Tet2 , a key driver of increased self-renewal in blood cancers. Using state-of-the...

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Literature Corpus work: 13dc8259-6d9d-51af-9aa7-83a9039ce66a
DOI: 10.1101/2025.01.20.633881

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