Article
Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.
Cell chemical biology - 19 Feb 2026
Kim Peter Geon, Hergott Christopher B, Miller Aidan P, Deik Amy, Boileau Meaghan, Bullock Kevin, Pierce Kerry A, Choy Angelina H, Shin Wesley, McConkey Marie, Loke Justin, Ryback Birgitta A, Trinh Michael N, Rutter Justine C, Yue Hong, Yoon Hojong, Park Paul, Roy Burman Shourya S, Vander Heiden Matthew G, Fischer Eric S, Armstrong Scott A, Clish Clary, Ebert Benjamin L
Abstract excerpt
Somatic mutations in TET2 drive hyper-inflammation in clonal hematopoiesis of indeterminate potential (CHIP), but the molecular link between TET2 inactivation and myeloid immune activation remains unclear. We used in vivo genome-wide genetic perturbations enabled by ultra-diverse barcoding in primary wild-type (WT) or Tet2 knockout (KO) Cas9+ hematopoietic stem-progenitor cells (HSPCs) to elucidate the basis of...
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