Low-input proteomics identifies vWF as a negative regulator of Tet2 mutant hematopoietic stem cell expansion.

doi:10.1016/j.celrep.2025.116770

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Article

Low-input proteomics identifies vWF as a negative regulator of Tet2 mutant hematopoietic stem cell expansion.

Cell reports - 27 Jan 2026

Jassinskaja Maria, Bode Daniel, Gonka Monika, Roumeliotis Theodoros I, Hogg Alexander J, Rubio Lara Juan A, Bennett Ellie, Milek Joanna, Elberfeld Samuel, Theeuwes Bart, Vijayabaskar M S, Cosme Lilia Cabrera, Chi Che James Lok, MacDonald Sandy, Ahmed Sophia, Hall Benjamin A, Vasey Grace, Kooi Helena, Belmonte Miriam, Shepherd Mairi S, Brackenbury William J, Kucinski Iwo, Yamazaki Satoshi, Holding Andrew N, Cull Alyssa H, Wilson Nicola K, Göttgens Berthold, Choudhary Jyoti, Kent David G

Abstract excerpt

Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), few studies exist at the protein level. We perform a deep, multi-omics characterization (epigenome, transcriptome, and proteome) of HSCs in a mouse model carrying a loss-of-function mutation in Tet2, a driver of increased self-renewal in blood cancers. Using state-of-the-art, multiplexed, low-input...

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Identifiers

PMID: 41447537
DOI: 10.1016/j.celrep.2025.116770
PMCID: PMC12847853

Genes

TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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