Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative analysis of Tet2 catalytic-deficient and knockout bone marrow over time.

Experimental hematology - 1 Aug 2023

Flores Julio C, Ito Kyoko, Huang Cheng-Yen, Tang Qin, Yanase Chie, Ito Keisuke, Dawlaty Meelad M

Abstract excerpt

TET2 is a member of the Ten-eleven translocation (Tet) family of DNA dioxygenases that regulate gene expression by promoting DNA demethylation (enzymatic activity) and partnering with chromatin regulatory complexes (nonenzymatic functions). TET2 is highly expressed in the hematopoietic lineage, where its molecular functions are the subject of continuous investigations because of the prevalence of TET2 mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Dioxygenases
Share to Hematologic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematologic Neoplasms

Share to Hematopoiesis

Share to Infant

Share to Mutation

Share to Myelodysplastic Syndromes

Source

Open in PubMed Open full text

Identifiers

PMID: 37225048
DOI: 10.1016/j.exphem.2023.05.004
PMCID: PMC10524687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative analysis of Tet2 catalytic-deficient and knockout bone marrow over time.PMID 37225048Read ↗

TET2 mutation as prototypic clonal hematopoiesis lesion.Semantic proximity Read ↗

TET2: A cornerstone in normal and malignant hematopoiesis.Semantic proximity Read ↗

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis.Semantic proximity Read ↗

Age-Associated TET2 Mutations: Common Drivers of Myeloid Dysfunction, Cancer and Cardiovascular Disease.Semantic proximity Read ↗

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cellsSemantic proximity Read ↗

TET2 as an epigenetic master regulator for normal and malignant hematopoiesis.Semantic proximity Read ↗

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in MiceSemantic proximity Read ↗

[TET2 as a gatekeeper for hematologic malignancies].Semantic proximity Read ↗

B-cell tumor development in Tet2-deficient mice.Semantic proximity Read ↗

TET2 in Normal and Malignant Hematopoiesis.Semantic proximity Read ↗

TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights.Semantic proximity Read ↗

TET2-CHIP: From Mutation to Malady.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.