Article

Deficiency of <i>Irx5</i> protects mice from diet-induced obesity and associated metabolic abnormalities

2021-09-27

Abstract excerpt

Obesity, a leading cause of several metabolic abnormalities, is mainly due to an imbalance of energy homeostasis. IRX3 and IRX5 have been suggested as determinants of obesity in connection with the intronic variants of FTO , the strongest genetic risk factor of polygenic obesity in humans. Although the causal effects of Irx3 on obesity and its related metabolic consequences have been demonstrated in vivo , th...

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Literature Corpus work: 1398c278-ca2f-540c-9524-19112a6331ed
DOI: 10.1101/2021.09.27.462004

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