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Article

Obesity and FTO: Changing Focus at a Complex Locus.

Cell metabolism - 4 Nov 2014

Tung Y C Loraine, Yeo Giles S H, O'Rahilly Stephen, Coll Anthony P

Abstract excerpt

The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic variants and FTO activity has remained elusive. Two recent reports now indicate that...

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Source

Identifiers

PMID: 25448700
DOI: 10.1016/j.cmet.2014.09.010

Genes

FTO
IRX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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