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Article

Mice harboring the obesity-associated SNP rs1421085 exhibit increased body weight and reveal an IRX3 neuronal circuit regulating body weight.

Molecular metabolism - 1 Oct 2025

Sullivan Andrew I, Flippo Kyle H, Aklan Iltan, Claflin Kristin E, Morgan Donald A, Naber Meghan C, Rahmouni Kamal, Potthoff Matthew J

Abstract excerpt

OBJECTIVE: The single nucleotide polymorphism (SNP) rs1421085 has one of the highest associated risks with obesity of any SNP in the human genome. Through the generation of a novel mouse model harboring rs1421085 (OA-SNPrs142/rs142), we examined the impact of this SNP on energy balance. Furthermore, we investigated the role of IRX3, a potential mediator of the metabolic effects of rs1421085, in multiple brain...

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Share to Body Weight
Share to Diet, High-Fat
Share to Eating
Share to Energy Metabolism
Share to Homeodomain Proteins
Share to Mice, Inbred C57BL
Share to Neurons
Share to Obesity

Source

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Identifiers

PMID: 40835181
DOI: 10.1016/j.molmet.2025.102234
PMCID: PMC12419104

Genes

IRX3

Provenance

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