Obesity-associated variants within FTO form long-range functional connections with IRX3.

doi:10.1038/nature13138

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Article

Obesity-associated variants within FTO form long-range functional connections with IRX3.

Nature - 20 Mar 2014

Smemo Scott, Tena Juan J, Kim Kyoung-Han, Gamazon Eric R, Sakabe Noboru J, Gómez-Marín Carlos, Aneas Ivy, Credidio Flavia L, Sobreira Débora R, Wasserman Nora F, Lee Ju Hee, Puviindran Vijitha, Tam Davis, Shen Michael, Son Joe Eun, Vakili Niki Alizadeh, Sung Hoon-Ki, Naranjo Silvia, Acemel Rafael D, Manzanares Miguel, Nagy Andras, Cox Nancy J, Hui Chi-Chung, Gomez-Skarmeta Jose Luis, Nóbrega Marcelo A

Abstract excerpt

Genome-wide association studies (GWAS) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes (T2D). Although the molecular mechanisms linking these noncoding variants with obesity are not immediately obvious, subsequent studies in mice demonstrated that FTO expression levels influence body mass and composition phenotypes. However, no direct connection...

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Identifiers

PMID: 24646999
DOI: 10.1038/nature13138
PMCID: PMC4113484

Genes

FTO
IRX3

Variants

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