Article
Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Science (New York, N.Y.) - 4 Jun 2021
Sobreira Débora R, Joslin Amelia C, Zhang Qi, Williamson Iain, Hansen Grace T, Farris Kathryn M, Sakabe Noboru J, Sinnott-Armstrong Nasa, Bozek Grazyna, Jensen-Cody Sharon O, Flippo Kyle H, Ober Carole, Bickmore Wendy A, Potthoff Matthew, Chen Mengjie, Claussnitzer Melina, Aneas Ivy, Nóbrega Marcelo A
Abstract excerpt
Whereas coding variants often have pleiotropic effects across multiple tissues, noncoding variants are thought to mediate their phenotypic effects by specific tissue and temporal regulation of gene expression. Here, we investigated the genetic and functional architecture of a genomic region within the FTO gene that is strongly associated with obesity risk. We show that multiple variants on a common haplotype...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.