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Article

Hypomorphism of Fto and Rpgrip1l causes obesity in mice.

The Journal of clinical investigation - 2 May 2016

Stratigopoulos George, Burnett Lisa Cole, Rausch Richard, Gill Richard, Penn David Barth, Skowronski Alicja A, LeDuc Charles A, Lanzano Anthony J, Zhang Pumin, Storm Daniel R, Egli Dieter, Leibel Rudolph L

Abstract excerpt

Noncoding polymorphisms in the fat mass and obesity-associated (FTO) gene represent common alleles that are strongly associated with effects on food intake and adiposity in humans. Previous studies have suggested that the obesity-risk allele rs8050136 in the first intron of FTO alters a regulatory element recognized by the transcription factor CUX1, thereby leading to decreased expression of FTO and retinitis...

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Source

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Identifiers

PMID: 27064284
DOI: 10.1172/JCI85526
PMCID: PMC4855930

Genes

FTO
CUX1
AKTIP
IRX3
IRX5
RBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypomorphism of Fto and Rpgrip1l causes obesity in mice.PMID 27064284Read ↗

Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling.Semantic proximity Read ↗

Obesity and FTO: Changing Focus at a Complex Locus.Semantic proximity Read ↗

Complex Relationship between Obesity and the Fat Mass and Obesity Locus.Semantic proximity Read ↗

Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.Semantic proximity Read ↗

Obesity-associated variants within FTO form long-range functional connections with IRX3.Semantic proximity Read ↗

FTO associations with obesity and telomere length.Semantic proximity Read ↗

The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.Semantic proximity Read ↗

IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk.Semantic proximity Read ↗

The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.Semantic proximity Read ↗

The composite alliance of FTO locus with obesity-related genetic variants.Semantic proximity Read ↗

Common variants near MC4R are associated with fat mass, weight and risk of obesity.Semantic proximity Read ↗

A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution.Semantic proximity Read ↗

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