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Article

A novel genetic mouse model of osteoporosis with double heterozygosity of Irx3 and Irx5 characterizes sex-dependent phenotypes in bone homeostasis.

Bone - 1 Jan 2025

Chen Xinyu, Dou Zhengchao, Son Joe Eun, Duan Meng, Yang Fei, Zhu Shankuan, Hui Chi-Chung

Abstract excerpt

Iroquois homeobox gene 3 (Irx3) and Irx5 encode transcription factors that play crucial roles in limb development and bone formation. Previous studies using knockout mice have revealed a role of Irx3 and Irx5 in osteogenesis in young adult mice. However, whether these genes are also essential for bone homeostasis in adulthood and contribute to bone diseases remain poorly understood. Osteoporosis is a disease...

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PMID: 39401533
DOI: 10.1016/j.bone.2024.117282

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