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Article

Irx3 and Irx5 in Ins2-Cre+ cells regulate hypothalamic postnatal neurogenesis and leptin response.

Nature metabolism - 1 May 2021

Son Joe Eun, Dou Zhengchao, Kim Kyoung-Han, Wanggou Siyi, Cha Vincent Su Bin, Mo Rong, Zhang Xiaoyun, Chen Xinyu, Ketela Troy, Li Xuejun, Huang Xi, Hui Chi-Chung

Abstract excerpt

Obesity is mainly due to excessive food intake. IRX3 and IRX5 have been suggested as determinants of obesity in connection with the intronic variants of FTO, but how these genes contribute to obesity via changes in food intake remains unclear. Here, we show that mice doubly heterozygous for Irx3 and Irx5 mutations exhibit lower food intake with enhanced hypothalamic leptin response. By lineage tracing and...

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PMID: 33859429
DOI: 10.1038/s42255-021-00382-y

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Irx3 and Irx5 in Ins2-Cre+ cells regulate hypothalamic postnatal neurogenesis and leptin response.PMID 33859429Read ↗

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