Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V.

Stem cell research - 1 Jun 2023

Busley Alexandra Viktoria, Kleinsorge Mandy, Cyganek Lukas

Abstract excerpt

Activating KRAS codon 12 gene variants are known to cause severe RAS-MAPK and PI3K-AKT signaling pathway hyperactivity and are frequently involved in the development of various carcinomas. Here, we describe the generation of a human iPSC line harboring the common oncogenic KRAS p.G12V variant by using CRISPR/Cas9 technology. The established KRASG12V iPSC line allows the study of oncogenic KRAS-induced signaling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Induced Pluripotent Stem Cells
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins p21(ras)

Share to Signal Transduction

Source

Identifiers

PMID: 37121193
DOI: 10.1016/j.scr.2023.103105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V.PMID 37121193Read ↗

Status of KRAS in iPSCs Impacts upon Self-Renewal and Differentiation Propensity.Semantic proximity Read ↗

Selective targeting of KRAS oncogenic alleles by CRISPR/Cas9 inhibits proliferation of cancer cells.Semantic proximity Read ↗

Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cellsSemantic proximity Read ↗

CRISPR and KRAS: a match yet to be made.Semantic proximity Read ↗

An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.Semantic proximity Read ↗

A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers.Semantic proximity Read ↗

Generation of a human induced pluripotent stem cell (iPSC, DVSi001-A) with a heterozygous mutation in KRAS (A209T).Semantic proximity Read ↗

CRISPR prime editing for unconstrained correction of oncogenic KRAS variants.Semantic proximity Read ↗

Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression.Semantic proximity Read ↗

CRISPR/Cas9-Mediated Knock-Out of KrasG12D Mutated Pancreatic Cancer Cell Lines.Semantic proximity Read ↗

Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing.Semantic proximity Read ↗

Endogenous oncogenic KRAS expression increases cell proliferation and motility in near-diploid hTERT RPE-1 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.