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Article

Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines.

Scientific reports - 23 Feb 2015

Stolze Britta, Reinhart Stefanie, Bulllinger Lars, Fröhling Stefan, Scholl Claudia

Abstract excerpt

KRAS mutations occur in one third of human cancers and cluster in several hotspots, with codons 12 and 13 being most commonly affected. It has been suggested that the position and type of amino acid exchange influence the transforming capacity of mutant KRAS proteins. We used MCF10A human mammary epithelial cells to establish isogenic cell lines that express different cancer-associated KRAS mutations (G12C, G12D,...

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Source

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Identifiers

PMID: 25705018
DOI: 10.1038/srep08535
PMCID: PMC4336936

Genes

KRAS
EGF
EGFR
PDK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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