Article
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
Carcinogenesis - 1 Nov 2006
Céspedes María Virtudes, Sancho Francesc Josep, Guerrero Silvia, Parreño Matilde, Casanova Isolda, Pavón Miguel Angel, Marcuello Eugenio, Trias Manuel, Cascante Marta, Capellà Gabriel, Mangues Ramon
Abstract excerpt
Different mutant amino acids in the Ras proteins lead to distinct transforming capacities and different aggressiveness in human tumors. K-Ras Asp12 (K12D) is more prevalent in benign than in malignant human colorectal tumors, whereas K-Ras Val12 (K12V) associates with more advanced and metastatic carcinomas, higher recurrence and decreased survival. Here, we tested, in a nude mouse xenograft model, whether...
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