Article

Positive selection affects the human ADLH2 gene expression: genetic adaptation to alcohol consumption

2021-09-13

Abstract excerpt

<title>Abstract</title> <p>ALDH2 is a key enzyme in alcohol metabolism that protects cells from acetaldehyde toxicity. Using iHS and <italic>F</italic><sub><italic>ST</italic></sub> statistics, we identified regulatory acting variants affecting <italic>ALDH2</italic> gene expression under positive selection in populations of European ancestry. Several SNPs (rs3184504, rs4766578, rs10774625, rs597808, rs653178, rs...

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Literature Corpus work: 1336ed6a-bdfe-5b11-8b13-188c7aafb162
DOI: 10.21203/rs.3.rs-891422/v1

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