Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ethnic related selection for an ADH Class I variant within East Asia.

PloS one - 2 Apr 2008

Li Hui, Gu Sheng, Cai Xiaoyun, Speed William C, Pakstis Andrew J, Golub Efim I, Kidd Judith R, Kidd Kenneth K

Abstract excerpt

BACKGROUND: The alcohol dehydrogenases (ADH) are widely studied enzymes and the evolution of the mammalian gene cluster encoding these enzymes is also well studied. Previous studies have shown that the ADH1B*47His allele at one of the seven genes in humans is associated with a decrease in the risk of alcoholism and the core molecular region with this allele has been selected for in some East Asian populations. As...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase
Share to Alcoholism
Share to Asia, Eastern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Homozygote

Share to Models, Statistical

Share to Multigene Family

Source

Open in PubMed Open full text

Identifiers

PMID: 18382665
DOI: 10.1371/journal.pone.0001881
PMCID: PMC2268739

Genes

ADH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ethnic related selection for an ADH Class I variant within East Asia.PMID 18382665Read ↗

Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia.Semantic proximity Read ↗

Evidence of positive selection on a class I ADH locus.Semantic proximity Read ↗

Diversification of the ADH1B gene during expansion of modern humans.Semantic proximity Read ↗

The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history.Semantic proximity Read ↗

A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity.Semantic proximity Read ↗

Genome-wide meta-analysis of alcohol use disorder in East Asians.Semantic proximity Read ↗

ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis.Semantic proximity Read ↗

Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism.Semantic proximity Read ↗

ADH1B: From alcoholism, natural selection, and cancer to the human phenome.Semantic proximity Read ↗

Genetic variation in alcohol metabolizing enzymes among Inuit and its relation to drinking patterns.Semantic proximity Read ↗

Natural positive selection and north-south genetic diversity in East Asia.Semantic proximity Read ↗

Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.