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Article

ADH1B: From alcoholism, natural selection, and cancer to the human phenome.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2018

Polimanti Renato, Gelernter Joel

Abstract excerpt

The ADH1B (Alcohol Dehydrogenase 1B (class I), Beta Polypeptide) gene and its best-known functional alleles, Arg48His (rs1229984, ADH1B*2) and Arg370Cys (rs2066702, ADH1B*3), have been investigated in relation to many phenotypic traits; most frequently including alcohol metabolism and alcohol drinking behaviors, but also human evolution, liver function, cancer, and, recently, the comprehensive human phenome. To...

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Identifiers

PMID: 28349588
DOI: 10.1002/ajmg.b.32523
PMCID: PMC5617762

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