Promoter Polymorphism rs886205 Genotype Interacts With DNA Methylation of the ALDH2 Regulatory Region in Alcohol Dependence.

doi:10.1093/alcalc/agw106

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Promoter Polymorphism rs886205 Genotype Interacts With DNA Methylation of the ALDH2 Regulatory Region in Alcohol Dependence.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 May 2017

Pathak Hansi, Frieling Helge, Bleich Stefan, Glahn Alexander, Heberlein Annemarie, Haschemi Nassab Mani, Hillemacher Thomas, Burkert Alexandra, Rhein Mathias

Abstract excerpt

AIMS: Aldehyde dehydrogenase 2 (ALDH2) protects cells from ethanol toxicity by metabolizing acetaldehyde. We studied the single nucleotide polymorphism (SNP) rs886205s located between a negative and a positive regulating promoter element in the ALDH2 gene. The negative regulatory region was already associated with differential DNA methylation in the two allele variations of rs886205 SNP. Another CpG island, in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldehyde Dehydrogenase, Mitochondrial

Share to Central Nervous System Depressants

Share to DNA Methylation

Share to Enzyme Induction

Share to Ethanol

Share to Sex Characteristics

Share to Testosterone

Source

Open in PubMed

Identifiers

PMID: 28430929
DOI: 10.1093/alcalc/agw106

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter Polymorphism rs886205 Genotype Interacts With DNA Methylation of the ALDH2 Regulatory Region in Alcohol Dependence.PMID 28430929Read ↗

Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients.Semantic proximity Read ↗

Genetics of Alcohol Dependence: A Review of Clinical StudiesSemantic proximity Read ↗

Genome-wide association study of alcohol dependence.Semantic proximity Read ↗

A Novel Polymorphism (‐357 G/A) of the ALDH2 Gene: Linkage Disequilibrium and an Association With AlcoholismSemantic proximity Read ↗

Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes.Semantic proximity Read ↗

Identifying genetic variation for alcohol dependenceSemantic proximity Read ↗

Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes.Semantic proximity Read ↗

Genome-wide DNA methylation analysis in alcohol dependence.Semantic proximity Read ↗

Genetics and Epigenetics of Aldehyde Dehydrogenase (ALDH2) in Alcohol Related Liver DiseaseSemantic proximity Read ↗

Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.Semantic proximity Read ↗

DNA Methylation change in genes involved in Alcohol metabolism (ALDH2) and One-carbon metabolism (MTHFR) pathways among people with Alcohol Use DisorderSemantic proximity Read ↗

Association of the ALDH1A1*2 promoter polymorphism with alcohol phenotypes in young adults with or without ALDH2*2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.