Positive selection acts on regulatory genetic variants in populations of European ancestry that affect ALDH2 gene expression.

Abstract excerpt

ALDH2 is a key enzyme in alcohol metabolism that protects cells from acetaldehyde toxicity. Using iHS, iSAFE and FST statistics, we identified regulatory acting variants affecting ALDH2 gene expression under positive selection in populations of European ancestry. Several SNPs (rs3184504, rs4766578, rs10774625, rs597808, rs653178, rs847892, ) that function as eQTLs for ALDH2 in various tissues showed...