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Article

Origin and Spread of the ALDH2 Glu504Lys Allele

20 Sept 2021

Abstract excerpt

Gene polymorphism of acetaldehyde dehydrogenase 2 (ALDH2), a key enzyme for alcohol metabolism in humans, can affect catalytic activity. The ALDH2 Glu504Lys mutant allele has a high-frequency distribution in East Asian populations and has been demonstrated to be associated with an increased risk of cardiovascular disease, stroke, and tumors. Available evidence suggests that the evolution of the ALDH2 gene has...

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PMID: 36939783
DOI: 10.1007/s43657-021-00017-y

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