Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of positive selection on a class I ADH locus.

American journal of human genetics - 1 Mar 2007

Han Yi, Gu Sheng, Oota Hiroki, Osier Michael V, Pakstis Andrew J, Speed William C, Kidd Judith R, Kidd Kenneth K

Abstract excerpt

The alcohol dehydrogenase (ADH) family of enzymes catalyzes the reversible oxidation of alcohol to acetaldehyde. Seven ADH genes exist in a segment of ~370 kb on 4q21. Products of the three class I ADH genes that share 95% sequence identity are believed to play the major role in the first step of ethanol metabolism. Because the common belief that selection has operated at the ADH1B*47His allele in East Asian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase
Share to Cluster Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethanol

Share to Genetics, Population

Share to Geography

Share to Linkage Disequilibrium

Share to Multigene Family

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 17273965
DOI: 10.1086/512485
PMCID: PMC1821113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of positive selection on a class I ADH locus.PMID 17273965Read ↗

Ethnic related selection for an ADH Class I variant within East Asia.Semantic proximity Read ↗

Diversification of the ADH1B gene during expansion of modern humans.Semantic proximity Read ↗

Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism.Semantic proximity Read ↗

A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity.Semantic proximity Read ↗

Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia.Semantic proximity Read ↗

ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.Semantic proximity Read ↗

Positive selection acts on regulatory genetic variants in populations of European ancestry that affect ALDH2 gene expression.Semantic proximity Read ↗

The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history.Semantic proximity Read ↗

Positive selection affects the human ADLH2 gene expression: genetic adaptation to alcohol consumptionSemantic proximity Read ↗

Considerable haplotype diversity within the 23kb encompassing the ADH7 gene.Semantic proximity Read ↗

ADH1B: From alcoholism, natural selection, and cancer to the human phenome.Semantic proximity Read ↗

Selection variability for Arg48His in alcohol dehydrogenase ADH1B among Asian populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.