Article
ADH4 intronic variations are associated with alcohol dependence: results from an Italian case-control association study.
Pharmacogenetics and genomics - 1 Feb 2012
Turchi Chiara, Piva Francesco, Solito Giovanni, Principato Giovanni, Buscemi Loredana, Tagliabracci Adriano
Abstract excerpt
OBJECTIVES: This study investigated the involvement of ADH4 gene polymorphisms in the susceptibility to alcohol use disorders. METHODS: Thirty-eight single-nucleotide polymorphisms (SNPs) in and around the ADH4 gene were investigated in 136 Italian alcoholics and 276 healthy controls. A new approach based on a bioinformatic method selected 26 SNPs that may affect the splicing sites, destroying or creating binding...
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