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Article

LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.

Nature communications - 14 Sept 2015

Choi Insup, Kim Beomsue, Byun Ji-Won, Baik Sung Hoon, Huh Yun Hyun, Kim Jong-Hyeon, Mook-Jung Inhee, Song Woo Keun, Shin Joo-Ho, Seo Hyemyung, Suh Young Ho, Jou Ilo, Park Sang Myun, Kang Ho Chul, Joe Eun-Hye

Abstract excerpt

In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-induced motility and delayed isolation of injury, compared with non-Tg microglia. Conversely, LRRK2 knockdown microglia are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26365310
DOI: 10.1038/ncomms9255
PMCID: PMC4647842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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